Plexiform Leiomyoma of the Soft Palate: A Case Study and Literature Review

Benign plexiform lesion may describe a rare tumor based on morphological features. Plexiform arrangement may suggest lesions which are spindled and focally show some whorling and fascicular pattern [1]. Literature has provided a vast differential diagnosis of plexiform lesion some of which include schwannoma, fibrohistiocytic tumors, angiomyxoid tumors, fibromyxoma [25]. Plexiform neurofibroma is another plexiform tumor shown to have predilection for the head and neck region. Case reports have shown plexiform neurofibromas in areas including, but not limited to the neck, parotid gland, aretynoid, maxillary sinus, and tongue [6-10]. Morphological features of a plexiform neurofibroma with an immunoreactivity profile for desmin and smooth muscle actin produces a rare variant of a benign plexiform lesion called plexiform leiomyoma. Plexiform leiomyoma’s presence has only been documented in the uterus and esophagus [1-11]. The following case study demonstrates the first ever finding of a plexiform leiomyoma outside the gastrointestinal tract and uterus located on the soft palate.